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Low serum IGF-1 is associated with elevated brain amyloid-beta levels, a hallmark of the pathogenesis of Alzheimers disease (52) (Figure 2)

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Epigallocatechin gallate (EGCG), a bioactive compound derived from green tea (Eng et al., 2018), has been demonstrated to inhibit the formation of D-2-hydroxyglutarate (D-2-HG) from glutamate, augmenting the radiosensitivity in IDH mutant cancers (Peeters et al., 2019)